First-to-market loses grip

Tankyrase Loses Its Grip on SH3BP2 in Cherubism

Cherubism, a case of bone remodeling gone haywire, is associated with mutations in the adaptor protein SH3BP2. Two papers in this issue of Cell (Guettler et al. and Levaot et al.) demonstrate that these mutations disrupt the interaction between SH3BP2 and Tankyrase and describe rules for substrate recognition by this poly(ADP-ribose) polymerase. Establishing such rules paves the way to identify...

Management and Market Reactions to Litigation: Do Shareholders Win When the Company Loses?

Human Grip Responses to Perturbations of Objects During Precision Grip

Grasp stability of a precision grip requires fine control of three-dimensional fingertip forces. This chapter begins with a review of the literature on how precision grip forces are affected by intrinsic object properties, anticipation, load direction, and sensory feedback. Previous studies have established that reactive, initial increases in grip forces (pulse-like ‘‘catch-up responses’’ in gr...

Sticky Solution Provides Grip for the First Robotic Pollinator

http://dx.doi.org/10.1016/j.chempr.2017.01.012 The first record of hand pollination was in a relief from an Assyrian dynasty, 800 BC, now preserved in the Boston Museum of Fine Arts. In the relief, shown in Figure 1A, two winged deities gingerly fertilize a date palm tree by using a male flower. Nearly 3,000 years later, pollination has been automated. In this issue of Chem, Chechetka et al. de...

HIV Pathogenesis: Nef Loses Control

In this issue of Cell, Schindler et al. (2006) show that the Nef protein from nonpathogenic strains of simian immunodeficiency virus (SIV) induces the downregulation of host T cell receptor/CD3, whereas Nef from human immunodeficiency virus (HIV-1) does not. This loss of function in the Nef of HIV-1 may partly explain the pathogenicity of this virus.